Sodium ion → 6-chloro-8-(5-fluoropyridin-2-ylamino)-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

HRID 138563

Reaction equation

HRID 138563 reaction equation
[Br:11][c:12]1[c:13]2[n:14]([n:15][c:16]([Cl:18])[cH:17]1)[c:19]([C:22](=[O:23])[NH:24][c:25]1[c:26]([F:31])[cH:27][n:28][cH:29][cH:30]1)[cH:20][n:21]2.[F:1][c:2]1[cH:3][cH:4][c:5]([NH2:8])[n:6][cH:7]1.[H-:10].[Na+:9].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37].[OH2:32]>>[F:1][c:2]1[cH:3][cH:4][c:5]([NH:8][c:12]2[c:13]3[n:14]([n:15][c:16]([Cl:18])[cH:17]2)[c:19]([C:22](=[O:23])[NH:24][c:25]2[c:26]([F:31])[cH:27][n:28][cH:29][cH:30]2)[cH:20][n:21]3)[n:6][cH:7]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 166653HydrideHCID 27377012-Amino-5-fluoropyridineHCID 596244958-Bromo-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

Product 1

HCID 596249056-chloro-8-(5-fluoropyridin-2-ylamino)-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

Sources & evidence

ORD record
ord-f41ca5483c3849b8a0537dde0015dc4f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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