3-Amino-4-methoxybenzanilide → 3-(3,5-Dichloro-benzenesulfonylamino)-4-methoxy-N-phenyl-benzamide

HRID 1387568

Reaction equation

HRID 1387568 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:5]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6].[Cl:19][C:20]1[CH:21]=[C:22]([S:27](Cl)(=[O:29])=[O:28])[CH:23]=[C:24]([Cl:26])[CH:25]=1>CN(C)C1C=CN=CC=1>[Cl:26][C:24]1[CH:23]=[C:22]([S:27]([NH:1][C:2]2[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=2[O:17][CH3:18])[C:5]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:6])(=[O:28])=[O:29])[CH:21]=[C:20]([Cl:19])[CH:25]=1

Participants

4

Reactant 2

HCID 84263-Amino-4-methoxybenzanilideHCID 5223883,5-Dichlorobenzenesulfonyl chloride

Product 1

HCID 98900163-(3,5-Dichloro-benzenesulfonylamino)-4-methoxy-N-phenyl-benzamideYield 74.6%

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Procedure

Prepared according to the procedure described for Example 116 using 3-amino-4-methoxy-N-phenyl-benzamide (0.7296 g, 3.00 mmol), 3,5-dichlorobenzenesulfonyl chloride (0.7327 g, 3.00 mmol), and 4-dimethylaminopyridine to obtain the product (1.01 g); m.p. 222-228° C.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d69486c89ed642828e9874e031d8c357
Source dataset
uspto-grants-2001_07
Patent number
US06268387B1

Linked notes

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