Methyl iodide → 1-Methyl-1-(4-(3-(4-fluorophenyl)cinnamoylamino)benzyl)piperidinium iodide
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([CH:29]=[CH:30][CH:31]=2)[CH:11]=[CH:12][C:13]([NH:15][C:16]2[CH:28]=[CH:27][C:19]([CH2:20][N:21]3[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:18][CH:17]=2)=[O:14])=[CH:4][CH:3]=1.[CH3:32][I:33]>CN(C)C=O>[I-:33].[CH3:32][N+:21]1([CH2:20][C:19]2[CH:27]=[CH:28][C:16]([NH:15][C:13](=[O:14])[CH:12]=[CH:11][C:10]3[CH:29]=[CH:30][CH:31]=[C:8]([C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)[CH:9]=3)=[CH:17][CH:18]=2)[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1Participants
4
Procedure
A solution of Compound 83 (0.25 g) and methyl iodide (0.2 ml) in dimethylformamide (5 ml) was stirred at room temperature over night. The solvent was evaporated, and to the residue was added ethyl acetate. Precipitated crude crystal was filtered, which were recrystallized from ethanol to give 1-methyl-1-(4-(3-(4-fluorophenyl) cinnamoylamino)-benzyl)piperidinium iodide (Compound 87) (0.27 g) as pale brown crystals.