Hydrochloric Acid → 7-(3-((2-(3,5-Dihydroxyphenyl)-2-oxoethyl)(phenylmethyl)amino)propyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrochloride
Reaction equation
[ClH:1].C([O:5][C:6]1[CH:7]=[C:8]([C:16](=[O:42])[CH2:17][N:18]([CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH2:19][CH2:20][CH2:21][N:22]2[C:31]3[C:30](=[O:32])[N:28]([CH3:29])[C:27](=[O:33])[N:26]([CH3:34])[C:25]=3[N:24]=[CH:23]2)[CH:9]=[C:10]([O:12]C(=O)C)[CH:11]=1)(=O)C.Cl>CO>[ClH:1].[OH:5][C:6]1[CH:7]=[C:8]([C:16](=[O:42])[CH2:17][N:18]([CH2:35][C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:19][CH2:20][CH2:21][N:22]2[C:31]3[C:30](=[O:32])[N:28]([CH3:29])[C:27](=[O:33])[N:26]([CH3:34])[C:25]=3[N:24]=[CH:23]2)[CH:9]=[C:10]([OH:12])[CH:11]=1Participants
4
Procedure
The wet product of step (b) containing 12.8 kg of diacetyl compound was added to 25.6 liters of methanol and 12.8 liters of 10% hydrochloric acid. The mixture was boiled for one hour at reflux, treated with some activated carbon and kieselguhr, filtered and allowed to cool. On the next day it was centrifuged, washed with water and dried.