Potassium Carbonate → N-Formyl-4-bromomethylpiperidine

HRID 1389769

Reaction equation

HRID 1389769 reaction equation
Br.[Br:2][CH2:3][CH:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[C:10](=O)([O-])[O-:11].[K+].[K+]>O.C(OC)=O>[CH:10]([N:7]1[CH2:8][CH2:9][CH:4]([CH2:3][Br:2])[CH2:5][CH2:6]1)=[O:11]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 135032174-(Bromomethyl)piperidine hydrobromide

Product 1

HCID 19812293N-Formyl-4-bromomethylpiperidine

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 7865Methyl formateSolvent

Procedure

To a solution of 4-bromomethylpiperidin hydrobromide (12.8 g, 0.05 mole) in water (5 ml), methyl formate (25 ml) and potassium carbonate (10 g) were added and the mixture stirred for 20 hours. The solvent was decanted, and the residue was extracted with two 25 ml portions of ether. The combined organic phases were washed with water, dried and evaporated to give (A) as a colourless oil. The IR spectrum (chloroform) showed a strong band at 1650 cm-1.

Workup

  1. customThe solvent was decanted
  2. extractionthe residue was extracted with two 25 ml portions of ether
  3. washThe combined organic phases were washed with water
  4. customdried
  5. customevaporated

Sources & evidence

ORD record
ord-54a83d9fc37c4287bd1bcfc5f8fc4ffa
Source dataset
uspto-grants-1981_01
Patent number
US04246262

Linked notes

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