2-Bromoethanol → 2-[(2-Pyridin-4-ylethyl)thio]ethanol

HRID 1389795

Reaction equation

[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][SH:9])=[CH:3][CH:2]=1.Br[CH2:11][CH2:12][OH:13]>>[OH:13][CH2:12][CH2:11][S:9][CH2:8][CH2:7][C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1

Participants

Reactant 2

HCID 108982-Bromoethanol

HCID 1509694-Pyridoethanethiol

Product 1

HCID 20584062-[(2-Pyridin-4-ylethyl)thio]ethanol

Procedure

Furthermore, by following this method 2-(4-pyridyl)ethyl mercaptan is reacted with 2-bromoethanol to yield 4-[2-(2-hydroxyethylthio)ethyl]pyridine, with 2-bromo-1-propanol to yield 4-[2-(2-hydroxy-1-propylthio)ethyl]pyridine, with 3-bromo-2-butanol to yield 4-[2-(3-hydroxy-2-butylthio)ethyl]pyridine, with ethyl 2-chloropropionate to yield ethyl 2-[2-(4-pyridyl)ethylthio]propionate, with methyl 2-phenyl-2-bromoacetate to yield methyl 2-phenyl-2-[2-(4-pyridyl)ethylthio]acetate, with alpha-bromoacetophenone to yield alpha-[2-(4-pyridyl)ethylthio]acetophenone, and with chloroacetone to yield 2-(4-pyridyl)ethylthioacetone.

Sources & evidence

ORD record: ord-b6a2ae8cc82d402bb4f73e482d4461b3
Source dataset: uspto-grants-1981_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04246263

Linked notes

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