2-Bromoethanol → 2-[(2-Pyridin-4-ylethyl)thio]ethanol
Reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][CH2:8][SH:9])=[CH:3][CH:2]=1.Br[CH2:11][CH2:12][OH:13]>>[OH:13][CH2:12][CH2:11][S:9][CH2:8][CH2:7][C:4]1[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=1Participants
3
Procedure
Furthermore, by following this method 2-(4-pyridyl)ethyl mercaptan is reacted with 2-bromoethanol to yield 4-[2-(2-hydroxyethylthio)ethyl]pyridine, with 2-bromo-1-propanol to yield 4-[2-(2-hydroxy-1-propylthio)ethyl]pyridine, with 3-bromo-2-butanol to yield 4-[2-(3-hydroxy-2-butylthio)ethyl]pyridine, with ethyl 2-chloropropionate to yield ethyl 2-[2-(4-pyridyl)ethylthio]propionate, with methyl 2-phenyl-2-bromoacetate to yield methyl 2-phenyl-2-[2-(4-pyridyl)ethylthio]acetate, with alpha-bromoacetophenone to yield alpha-[2-(4-pyridyl)ethylthio]acetophenone, and with chloroacetone to yield 2-(4-pyridyl)ethylthioacetone.
Sources & evidence
- ORD record
- ord-b6a2ae8cc82d402bb4f73e482d4461b3
- Source dataset
- uspto-grants-1981_01