Pyridine, 2-(4-methoxyphenoxy)-5-(trifluoromethyl)- → 4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol

HRID 1389903

Reaction equation

HRID 1389903 reaction equation
C[O:2][C:3]1[CH:19]=[CH:18][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][N:9]=2)=[CH:5][CH:4]=1.Cl.N1C=CC=CC=1>O.Cl>[OH:2][C:3]1[CH:19]=[CH:18][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:10][N:9]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 155242Pyridine, 2-(4-methoxyphenoxy)-5-(trifluoromethyl)-HCID 10176127Pyridinium chloride

Product 1

HCID 1552414-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

The product from (c) (1.7 g) and excess of pyridine hydrochloride were heated together for 8 hours at 180° C. The mixture was cooled, diluted with water and 2-molar hydrochloric acid, and extracted with ether. The extracts were dried and evaporated to yield an oil identified as the required hydroxy compound.

Workup

  1. temperatureThe mixture was cooled
  2. extractionextracted with ether
  3. customThe extracts were dried
  4. customevaporated
  5. customto yield an oil

Sources & evidence

ORD record
ord-397b0ef1c3094488bdaa5eb57e0084bd
Source dataset
uspto-grants-1981_01
Patent number
US04246419

Linked notes

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