3,4-Difluorobenzylamine → HCID 20729568, compound
Reaction equation
ClC(Cl)(Cl)[C:3]([C:5]1[NH:9][CH:8]=[C:7]([C:10](=[O:13])[CH2:11][CH3:12])[CH:6]=1)=[O:4].[F:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:20][NH2:21]>CN(C=O)C>[F:16][C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][C:24]=1[F:25])[CH2:20][NH:21][C:3]([C:5]1[NH:9][CH:8]=[C:7]([C:10](=[O:13])[CH2:11][CH3:12])[CH:6]=1)=[O:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of compound 2 (1 equivalent) in DMF, at ambient temperature, was added 3,4-difluorobenzyl amine (1.2 equivalents). After 24 hours, the solvent was evaporated and the crude product 5 was used without purification.
Workup
- customthe solvent was evaporated
- customthe crude product 5 was used without purification
Sources & evidence
- ORD record
- ord-6d30ce794eb94e78ab7f795b0979a0b4
- Source dataset
- uspto-grants-2008_03
- Patent number
- US07345054B2
Reaction notes
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