Acetate → Tert-butyl 3-(2-amino-5-bromo-3-pyridinyl)prop-2-enoate

Reaction equation

[Br:1][c:2]1[cH:3][c:4]([I:9])[c:5]([NH2:8])[n:6][cH:7]1.[C:10]([CH:11]=[CH2:12])(=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18].[C:19](#[N:20])[CH2:21][CH3:22].[O-:24][C:25]([CH3:26])=[O:27].[O-:28][C:29]([CH3:30])=[O:31].[O:32]=[CH:33][N:34]([CH3:35])[CH3:36].[Pd+2:23]>>[Br:1][c:2]1[cH:3][c:4]([CH:12]=[CH:11][C:10](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[c:5]([NH2:8])[n:6][cH:7]1

Participants

Reactant 6

HCID 175Acetate2×

HCID 6228Dimethylformamide

HCID 7854Propionitrile

HCID 15458tert-Butyl acrylate

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 15165082-Amino-5-bromo-3-iodopyridine

Product 1

Sources & evidence

ORD record: ord-985fff449bab460aa9603e14bcc281c3
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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