Sodium Carbonate → p-Aminopropiophenone
Reaction equation
[C:1]([C:5]1[CH:14]=[CH:13][C:8]([NH:9]C(=O)C)=[CH:7][CH:6]=1)(=[O:4])[CH2:2][CH3:3].C(=O)([O-])[O-].[Na+].[Na+]>Cl>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([NH2:9])=[CH:13][CH:14]=1)(=[O:4])[CH2:2][CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
141 g (1 mole) of p-propionylacetanilide were dissolved while refluxing and stirring into 600 ml of 5 N hydrochloric acid. Refluxing was continued for 30 min, cooling was applied, and sodium carbonate (about 300 g) was added, until the reaction mixture was alkaline. The residue formed was sucked off, washed with water until neutral and recrystallized from 725 ml of isopropanol. The mixture was sucked off and washed with ether. After drying under vacuum, a yellow-brownish powder was obtained.
Workup
- temperaturewhile refluxing
- temperatureRefluxing
- temperaturecooling
- customThe residue formed
- washwashed with water until neutral and
- customrecrystallized from 725 ml of isopropanol
- washwashed with ether
- customAfter drying under vacuum
- customa yellow-brownish powder was obtained
Sources & evidence
- ORD record
- ord-dddf784d330f4a969843da8cb504e923
- Source dataset
- uspto-grants-1980_05
- Patent number
- US04202697
Reaction notes
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