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Hydrochloric Acid → HCID 20339409, compound

HRID 1395460
Notes
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Reaction equation

HRID 1395460 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][N:9]1[CH2:27][CH2:26][N:12]2[C:13]3[C:18]([NH:19][C:20](=[O:21])[CH:11]2[CH2:10]1)=[CH:17][C:16]([C:22]([F:25])([F:24])[F:23])=[CH:15][CH:14]=3.C(O)C.Cl>[Pt]=O.O>[F:25][C:22]([F:23])([F:24])[C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[N:12]1[CH2:26][CH2:27][N:9]([CH2:8][CH2:7][CH:2]3[CH2:3][CH2:4][CH2:5][CH2:6][NH:1]3)[CH2:10][CH:11]1[C:20](=[O:21])[NH:19]2
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 20339412HCID 20339412, compound

Product 1

HCID 20339409HCID 20339409, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 962WaterSolvent

Procedure

A mixture of 5 g. (0.014 mole) of 2,3,4,4a-tetrahydro-3-[2-(2-pyridinyl)ethyl]-8-(trifluoromethyl)-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one, 60 ml. of ethanol, 120 ml. of water, 12 ml. of concentrated hydrogen chloride and 1 g. of platinum oxide catalyst is hydrogenated in a Parr apparatus for 2 hours. The catalyst is filtered and the solvents removed. The residue was crystallized from ethanol and recrystallized from methanol to yield 4.5 g. of the title compound as the dihydrochloride salt, m.p. 283°-286° C. (dec.).

Workup

  1. additionA mixture of 5 g
  2. filtrationThe catalyst is filtered
  3. customthe solvents removed
  4. customThe residue was crystallized from ethanol
  5. customrecrystallized from methanol
  6. customto yield 4.5 g

Sources & evidence

ORD record
ord-ee4e19f7ba0542599e245edbc26ea9d9
Source dataset
uspto-grants-1980_05
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US04203987

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes