Hydrochloric Acid → HCID 178479189, compound
Reaction equation
C([NH:4][CH2:5][C:6]1[S:10][C:9]([SH:11])=[N:8][N:7]=1)(=O)C.[ClH:12]>>[ClH:12].[NH2:4][CH2:5][C:6]1[S:10][C:9]([SH:11])=[N:8][N:7]=1Participants
3
Procedure
Thus obtained 5-acetamidomethyl-1,3,4-thiadiazole-2-thiol (44 g) was suspended in 6 N hydrochloric acid (400 ml) and the mixture was heated to reflux for 2 hours. The reaction mixture was allowed to cool, and the precipitates were collected by filtration and washed with ethanol to give 5-aminomethyl-1,3,4-thiadiazole-2-thiol hydrochloride (28.3 g). m.p. 213° to 217° C. The mother liquid obtained above was concentrated under reduced pressure and the residue was washed with ether to give the same objective product (12.6 g). Total yield is 40.9 g.
Workup
- temperaturethe mixture was heated
- temperatureto reflux for 2 hours
- temperatureto cool
- filtrationthe precipitates were collected by filtration
- washwashed with ethanol
Sources & evidence
- ORD record
- ord-4c00ed28544441d5af888959d708697d
- Source dataset
- uspto-grants-1980_05
- Patent number
- US04205166
Reaction notes
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