HCID 86632878, compound → HCID 68737602, compound
Reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N+:10]([O-])=O)[C:5]=1[NH:13][CH2:14][CH2:15][CH2:16][OH:17])([O-])=O>[Pd].O1CCCC1>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH2:10])[C:5]=1[NH:13][CH2:14][CH2:15][CH2:16][OH:17]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
Under hydrogen gas atmosphere, a mixture of 3-[(2,6-dinitrophenyl)amino]propan-1-ol (Reference Example 114; 17.7 g, 73.3 mmol), 10% palladium on carbon (50% wet, 3.5 g) and tetrahydrofuran (360 mL) was stirred at room temperature for 6 hr. The reaction mixture was filtered and concentrated in vacuo to give the title compound as an oil (12.1 g, 66.7 mmol, 91%).
Workup
- filtrationThe reaction mixture was filtered
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-66fa1d73ef42472496fac7f60287b43b
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08901141B2
Reaction notes
Loading…