Ethyl 3-hydroxybenzoate → 3-(Tetrahydropyran-4-yloxy)benzoic acid

Reaction equation

[OH:1][CH:2]1[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.O[C:9]1[CH:10]=[C:11]([CH:17]=[CH:18][CH:19]=1)[C:12]([O:14]CC)=[O:13]>>[O:5]1[CH2:6][CH2:7][CH:2]([O:1][C:9]2[CH:10]=[C:11]([CH:17]=[CH:18][CH:19]=2)[C:12]([OH:14])=[O:13])[CH2:3][CH2:4]1

Participants

Reactant 2

HCID 24522Ethyl 3-hydroxybenzoate

HCID 74956Tetrahydro-4H-pyran-4-ol

Product 1

HCID 231490603-(Tetrahydropyran-4-yloxy)benzoic acid

Procedure

Prepared from 4-hydroxy-tetrahydropyrane and ethyl 3-hydroxybenzoate. LC-MS (m/z): 245 (M−23 (Na)).

Sources & evidence

ORD record: ord-5383d127b0a64ef49a4d1428769251f0
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08907096B2

Reaction notes

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