2-(4-Methylphenyl)acetyl chloride → Ethyl 3-[2-(4-methylphenyl)-n-phenylacetamido]propanoate

HRID 1402931

Reaction equation

HRID 1402931 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](Cl)=[O:10])=[CH:4][CH:3]=1.[C:12]1([NH:18][CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([N:18]([CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27606342-(4-Methylphenyl)acetyl chlorideHCID 10910393beta-Alanine, N-phenyl-, ethyl ester

Product 1

HCID 66759712Ethyl 3-[2-(4-methylphenyl)-n-phenylacetamido]propanoate

Procedure

By a procedure similar to that of example 1.115.1, starting from 4-methylphenylacetyl chloride and ethyl N-phenyl-3-aminopropionate, ethyl 3-[2-(4-methylphenyl)-N-phenylacetamido]propanoate was obtained as yellowish oil.

Sources & evidence

ORD record
ord-cd7e82fdcf1442ebbd3eb69f56b326c9
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Linked notes

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