Ammonia → Ethyl 4-amino-2-fluoro-5-nitrobenzoate
Reaction equation
[CH2:1]([O:3][C:4](=[O:16])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8](F)=[CH:7][C:6]=1[F:15])[CH3:2].[NH3:17]>C1COCC1>[NH2:17][C:8]1[C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:16])=[C:6]([F:15])[CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared analogously to example 156b from 2,4-difluoro-5-nitrobenzoic acid-ethyl ester and conc. ammonia (aq) in THF.
Sources & evidence
- ORD record
- ord-eb2d27f6d2de4226bffd615fc3c1ec10
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08916599B2
Reaction notes
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