Hydrazine hydrate (1:1) → HCID 178474518, compound
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH:9]=[CH:10][N:11](C)C)=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:19])[CH3:18].O.[NH2:21]N>CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][NH:11][N:21]=2)=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:19])[CH3:18]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of N-[[2-chloro-5-[3-(dimethylamino)-1-oxo-2-propen-1-yl]phenyl]methyl]-acetamide (i.e. the product of Step A) (10.0 g, 35.7 mmol) and hydrazine hydrate (2.6 mL, 53.6 mmol) in methanol (100 mL) was stirred at room temperature for 20 h. The reaction mixture was then cooled to −5° C. and filtered, resulting in the title product as a solid (2.0 g), which was used in the next step without purification.