Cyanuric chloride → 4,6-dichloro-N-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine

Reaction equation

Cl[C:2]1[N:7]=[C:6]([Cl:8])[N:5]=[C:4]([Cl:9])[N:3]=1.[NH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1>>[Cl:9][C:4]1[N:5]=[C:6]([Cl:8])[N:7]=[C:2]([NH:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[N:3]=1

Participants

Reactant 2

HCID 7954Cyanuric chloride

HCID 195092-Pyridinemethanamine

Product 1

HCID 585080344,6-dichloro-N-(pyridin-2-ylmethyl)-1,3,5-triazin-2-amine

Procedure

Following the general procedure A, 2,4,6-trichloro-1,3,5-triazine was coupled with 2-aminomethylpyridine with reaction time of 2 h. Purification by column chromatography gave the title compound.

Workup

customPurification by column chromatography

Sources & evidence

ORD record: ord-3304ad77b56345898d5ba7c3abe86fc0
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08921361B2

Reaction notes

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