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Dichloromethane → 1-[1-(Tert-butoxycarbonyl)piperidin-4-ylmethyl]-4-(chloromethanesulfonyl)-2-piperazinone

HRID 140917
Notes
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Reaction equation

HRID 140917 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]2[C:16](=[O:21])[CH2:17][NH:18][CH2:19][CH2:20]2)[CH2:12][CH2:13]1.[CH3:22][CH2:23][N:24]([CH2:25][CH3:26])[CH2:27][CH3:28].[Cl:29][CH2:30][S:31](=[O:32])(=[O:33])[Cl:34].[Cl:35][CH2:36][Cl:37]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]2[C:16](=[O:21])[CH2:17][N:18]([S:31]([CH2:30][Cl:29])(=[O:32])=[O:33])[CH2:19][CH2:20]2)[CH2:12][CH2:13]1
ParticipantsSources & evidenceReaction notes

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 77054(Chloromethyl)sulfonyl chlorideHCID 234475144-(2-Oxo-piperazin-1-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 234473251-[1-(Tert-butoxycarbonyl)piperidin-4-ylmethyl]-4-(chloromethanesulfonyl)-2-piperazinone

Sources & evidence

ORD record
ord-6c354a8d42284687bf72480e2a81bb5d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI
10.1039/C8SC04228D

Reaction notes

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On this pageParticipantsSources & evidenceReaction notes