6-Hydroxy-2-naphthoic acid → 6-Hydroxy-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid

HRID 1410

Reaction equation

HRID 1410 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([OH:14])=[O:13])[CH:6]=[CH:5]2.[H][H]>[Pd].O1CCCC1>[OH:1][CH:2]1[CH2:11][CH2:10][C:9]2[CH:8]=[C:7]([C:12]([OH:14])=[O:13])[CH:6]=[CH:5][C:4]=2[CH2:3]1

Participants

5

Reactant 2

HCID 855576-Hydroxy-2-naphthoic acidHCID 178418361HCID 178418361, compound

Product 1

HCID 190699716-Hydroxy-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

For example, 6-hydroxynaphthalene-2-carboxylic acid in a solvent such as tetrahydrofuran is reduced with hydrogen gas in the presence of a reducing catalyst such as a palladium/carbon under elevated pressure to obtain 5,6,7,8-tetrahydro-6-hydroxynaphthalene-2-carboxylic acid (1).

Sources & evidence

ORD record
ord-ec5852a39378408dbba1f53767eea48c
Source dataset
uspto-grants-1998_03
Patent number
US05725798

Linked notes

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