1,1'-Thiocarbonyldi-2(1H)-pyridone → HCID 86646334, compound
Reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])[CH:5]=[CH:6][C:7]=1[Cl:8].[C:15](N1C=CC=CC1=O)(N1C=CC=CC1=O)=[S:16]>CN(C1C=CN=CC=1)C.C(Cl)Cl>[Cl:8][C:7]1[CH:6]=[CH:5][C:4]([CH:9]([NH:11][C:12](=[O:14])[CH3:13])[CH3:10])=[CH:3][C:2]=1[N:1]=[C:15]=[S:16]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
N-[1-(3-Amino-4-chlorophenyl)ethyl]acetamide (90 mg, 0.2 mmol) was added to a mixture of 1,1′-thiocarbonyldi-2-pyridone (69 mg, 0.2 mmol), DMAP (7 mg, 0.05 mmol) and DCM (2 mL) at rt. The mixture was concentrated and used in the next step without further purification.
Workup
- concentrationThe mixture was concentrated
- customused in the next step without further purification
Sources & evidence
- ORD record
- ord-3d8ff490b6f8494db2991573d585605c
- Source dataset
- uspto-grants-2014_12
- Patent number
- US08921405B2
Reaction notes
Loading…