Sodium ion → Tert-butyl 4-[[7-(4-bromo-2,5-difluorophenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate

HRID 141094

Reaction equation

HRID 141094 reaction equation
[Br:17][c:18]1[cH:19][c:20]([F:35])[c:21]([N:25]2[CH2:26][CH2:27][c:28]3[c:29]2[n:30][cH:31][n:32][c:33]3[Cl:34])[cH:22][c:23]1[F:24].[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[H-:16].[Na+:15].[OH2:41].[OH:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1>>[O:1]([CH:2]1[CH2:3][CH2:4][N:5]([C:8](=[O:9])[O:10][C:11]([CH3:12])([CH3:13])[CH3:14])[CH2:6][CH2:7]1)[c:33]1[c:28]2[c:29]([n:30][cH:31][n:32]1)[N:25]([c:21]1[c:20]([F:35])[cH:19][c:18]([Br:17])[c:23]([F:24])[cH:22]1)[CH2:26][CH2:27]2

Participants

7

Reactant 6

HCID 923Sodium ionHCID 962WaterHCID 8028TetrahydrofuranHCID 166653HydrideHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylateHCID 866373977-(4-Bromo-2,5-difluorophenyl)-4-chloro-5,6-dihydropyrrolo[2,3-d]pyrimidine

Product 1

HCID 58017031Tert-butyl 4-[[7-(4-bromo-2,5-difluorophenyl)-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-d81e251edd6b448f8651c978245e22a9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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