Methanol → Methyl 2-(6-aminopyridin-3-yloxy)-4-fluorobenzoate

HRID 141104

Reaction equation

HRID 141104 reaction equation
[Br:17][c:18]1[c:19]([C:20](=[O:21])[O:22][CH3:23])[cH:24][cH:25][c:26]([F:28])[cH:27]1.[CH2:31]([O:32][CH3:36])[CH2:33][O:34][CH3:35].[CH3:1][C:2]1([CH3:3])[C:4]([CH3:5])([CH3:6])[O:7][B:8]([c:9]2[cH:10][cH:11][c:12]([NH2:15])[n:13][cH:14]2)[O:16]1.[CH3:29][OH:30].[Pd:37]([Cl:38])[Cl:39].[c:40]1([P:41]([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[cH:54][cH:55][cH:56][cH:57][cH:58]1.[c:59]1([P:60]([c:61]2[cH:62][cH:63][cH:64][cH:65][cH:66]2)[c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[cH:73][cH:74][cH:75][cH:76][cH:77]1>>[c:9]1([O:32][c:18]2[c:19]([C:20](=[O:21])[O:22][CH3:23])[cH:24][cH:25][c:26]([F:28])[cH:27]2)[cH:10][cH:11][c:12]([NH2:15])[n:13][cH:14]1

Participants

7

Reactant 6

HCID 887MethanolHCID 80711,2-DimethoxyethaneHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 27565555-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amineHCID 7210837Methyl 2-bromo-4-fluorobenzoate

Product 1

HCID 67226188Methyl 2-(6-aminopyridin-3-yloxy)-4-fluorobenzoate

Sources & evidence

ORD record
ord-f66de21b73084efbbddeb127e804c899
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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