Hydrochloric Acid → 4-[(Prop-2-yn-1-yl)sulfanyl]benzene-1,2-diamine
Reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][C:10]#[CH:11])=[CH:4][C:3]=1[N+:12]([O-])=O.Cl.C(=O)(O)[O-].[K+]>C(Cl)(Cl)Cl>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][C:10]#[CH:11])=[CH:4][C:3]=1[NH2:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
4.8 G. of 1-amino-2-nitro-4-(prop-2-yn-1-ylthio)benzene in 14 ml. concentrated hydrochloric acid is treated with a solution of 24 g. stannous chloride in 14 ml. concentrated hydrochloric acid at 20°-30° C. After about 30 minutes, the mixture is neutralized with a saturated solution of potassium bicarbonate and chloroform added. The mixture is filtered, the chloroform layer separated, dried and evaporated yielding 1,2-diamino-4-(prop-2-yn-1-ylthio)benzene.
Workup
- customat 20°-30° C
- additionadded
- filtrationThe mixture is filtered
- customthe chloroform layer separated
- customdried
- customevaporated
Sources & evidence
- ORD record
- ord-0eb4838e1e394108b67530b1cf3546b7
- Source dataset
- uspto-grants-1977_01
- Patent number
- US04002640
Reaction notes
Loading…