Cephalexin Monohydrate → Cephalexin sodium salt

HRID 1415708

Reaction equation

HRID 1415708 reaction equation
[CH3:1][C:2]1[CH2:21][S:20][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:22]([OH:24])=[O:23].O.C(=O)(O)[O-].[Na+:30]>O>[CH3:1][C:2]1[CH2:21][S:20][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:19])[C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:22]([O-:24])=[O:23].[Na+:30]

Participants

4

Reactant 2

HCID 62921Cephalexin MonohydrateHCID 516892Sodium Bicarbonate

Product 1

HCID 23667618Cephalexin sodium saltYield 95%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

25 gms of cephalexin monohydrate was suspended in 75 ml of water. To this under stirring, 5.75 gms of sodium bicarbonate was added. The solution were filtered and lyophilized to afford 24 gms of crystalline cephalexin sodium.

Workup

  1. filtrationThe solution were filtered

Sources & evidence

ORD record
ord-65e39593c25049fb9aaf2b8d7e339214
Source dataset
uspto-grants-1999_06
Patent number
US05908929

Linked notes

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