Water → HCID 18781954, compound
Reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][CH:9]=[CH2:10])=[O:6].[C:11]([O-:14])(=[S:13])[CH3:12].[K+].O>CN(C)C=O>[C:11]([S:13][CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][CH:9]=[CH2:10])=[O:6])(=[O:14])[CH3:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Allyl 4-bromobutyrate (19.7 g) was treated with potassium thioacetate (10.9 g) in dimethyl formamide (100 ml) at 20° C. for 2 hours. Water (500 ml) was added and the mixture extracted with diethyl ether. The ethereal solution was washed with dilute aq. HCl, brine, dried (MgSO4) and evaporated to give the title compound as an oil (18.6 g, 97%)
Workup
- extractionthe mixture extracted with diethyl ether
- washThe ethereal solution was washed with dilute aq. HCl, brine
- dry with materialdried (MgSO4)
- customevaporated
Sources & evidence
- ORD record
- ord-b9291264b8d44e3c9fbe8b8d145161ba
- Source dataset
- uspto-grants-2000_06
- Patent number
- US06071899
Reaction notes
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