HomeMCPWorkbenchSkills
HomeWorkbenchNotificationsMe
llms.txt · MCP GuidePrivacy Policy · Terms of Service · Supportv1.8.0
  1. Home
  2. /Reaction

Water → 4-(p-Toluenesulfonylmethyl)-2,6-dihydroxymethyl-s-triazine

HRID 1421677
Notes
Print preview

Reaction equation

HRID 1421677 reaction equation
O[CH2:2][C:3]1[N:8]=[C:7]([CH2:9][OH:10])[N:6]=[C:5]([CH2:11][OH:12])[N:4]=1.N1C=CC=CC=1.[C:19]1([CH3:29])[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1.O>C(Cl)Cl>[C:19]1([CH3:29])[CH:24]=[CH:23][C:22]([S:25]([CH2:2][C:3]2[N:8]=[C:7]([CH2:9][OH:10])[N:6]=[C:5]([CH2:11][OH:12])[N:4]=2)(=[O:27])=[O:26])=[CH:21][CH:20]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 223236642,4,6-Trihydroxymethyl-s-triazine

Product 1

HCID 223236944-(p-Toluenesulfonylmethyl)-2,6-dihydroxymethyl-s-triazine

Reagents, catalysts & solvents 1

HCID 6344
Dichloromethane
Solvent
2×

Procedure

2,4,6-Trihydroxymethyl-s-triazine (1 eq.) is dissolved in an excess of pyridine. p-Toluenesulfonylchloride (0.9 eq.) in CH2Cl2 is added and the reaction mixture is stirred overnight. The solvent volume is reduced to a slurry to which water and dichloromethane are added and the resulting mixture is extracted with CH2Cl2. The combined CH2Cl2 layers are dried (MgSO4) and concentrated to an oil. The oil is purified by silica gel flash column chromatography to give the title compound.

Workup

  1. additionare added
  2. extractionthe resulting mixture is extracted with CH2Cl2
  3. dry with materialThe combined CH2Cl2 layers are dried (MgSO4)
  4. concentrationconcentrated to an oil
  5. customThe oil is purified by silica gel flash column chromatography

Sources & evidence

ORD record
ord-a096e5a92b304f6b8ec51664f6e477f4
Source dataset
uspto-grants-2000_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06077954

Reaction notes

Loading…

On this pageParticipantsProcedureWorkupSources & evidenceReaction notes