Toluene → Methyl 4,4-difluoro-3-oxo-2-(piperidin-1-ylmethylidene)butyrate

HRID 142174

Reaction equation

HRID 142174 reaction equation
[CH3:13][CH2:14][N:15]([CH2:16][CH3:17])[CH2:18][CH3:19].[CH3:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1.[F:20][CH:21]([C:22](=[O:23])[Cl:24])[F:25].[N:1]1([CH:7]=[CH:8][C:9](=[O:10])[O:11][CH3:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1>>[N:1]1([CH:7]=[C:8]([C:9](=[O:10])[O:11][CH3:12])[C:22]([CH:21]([F:20])[F:25])=[O:23])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 8471TriethylamineHCID 27368902,2-Difluoroacetyl chlorideHCID 66920573Methyl 3-piperidin-1-ylacrylate

Product 1

HCID 86651359Methyl 4,4-difluoro-3-oxo-2-(piperidin-1-ylmethylidene)butyrate

Sources & evidence

ORD record
ord-f0b536a1c52543b3966b2f896c9f1933
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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