Chlorosuccinimide → HCID 67548928, compound

Reaction equation

[CH3:1][C:2]1[NH:6][C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[N:4][CH:3]=1.C1C(=O)N([Cl:19])C(=O)C1>>[Cl:19][C:3]1[N:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[NH:6][C:2]=1[CH3:1]

Participants

Reactant 2

HCID 31398Chlorosuccinimide

HCID 24974466Ethyl 5-methyl-1H-imidazole-2-carboxylate

Product 1

HCID 67548928HCID 67548928, compoundYield 82.1%

Procedure

The same operation as in Example (1c) was performed using ethyl 5-methyl-1H-imidazole-2-carboxylate obtained in Example (5a) (0.50 g, 3.23 mmol) and NCS (0.44 g, 3.25 mmol), to obtain 0.50 g of the title compound as a white solid (82%).

Sources & evidence

ORD record: ord-ba1da1aa692f45ee90161a371a08174b
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927588B2

Reaction notes

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