Ammonium Chloride → 4-Chloropyridine-2-carboximidamide hydrochloride

HRID 1431925

Reaction equation

HRID 1431925 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]#[N:9])[CH:3]=1.C[O-].[Na+].[Cl-].[NH4+:14]>CO>[ClH:1].[C:8]([C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][N:5]=1)(=[NH:14])[NH2:9]

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 6933424-Chloro-2-pyridinecarbonitrileHCID 10942334Sodium Methoxide

Product 1

HCID 218820004-Chloropyridine-2-carboximidamide hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

6.93 g (50 mmol) of 4-chloro-2-cyanopyridine in 40 ml of methanol are treated for one hour with 0.27 g (5 mmol) sodium methoxide. After the addition of 3.00 g (56 mmol) of ammonium chloride, refluxing is carried out for two hours. The volatile components are then removed in vacuo. The 2-amidino-4-chloropyridine hydrochloride so obtained is reacted without further purification.

Workup

  1. temperaturerefluxing
  2. customThe volatile components are then removed in vacuo

Sources & evidence

ORD record
ord-240063da68164b27b7977e65dd3e8129
Source dataset
uspto-grants-2009_11
Patent number
US07612010B2

Linked notes

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