Hydrochloric Acid → Methyl 3-(sec-butylcarbamoyl)acrylate

HRID 14348

Reaction equation

[CH:1]([NH:5][C:6]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])=[O:7])([CH2:3][CH3:4])[CH3:2].Cl.[CH3:14]O>>[CH:1]([NH:5][C:6]([CH:8]=[CH:9][C:10]([O:12][CH3:14])=[O:11])=[O:7])([CH2:3][CH3:4])[CH3:2]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 2445953-(Sec-butylcarbamoyl)acrylic acid

Product 1

HCID 54128810Methyl 3-(sec-butylcarbamoyl)acrylate

Procedure

To 3-(sec butylcarbamoyl)acrylic acid (20 g, 117 mmol) at room temperature was added 150 mL 1.2M HCl in methanol. The resulting mixture was stirred for two hours. Solvents were removed in vacuo to give the desired ester, which was used without further purification.

Workup

customSolvents were removed in vacuo

Sources & evidence

ORD record: ord-fd21e8724b114687a300e5cced105f64
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07732018B2

Linked notes

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