2-Bromopyridine → 2-(2-Amino-5-bromobenzoyl)pyridine

HRID 1435811Notes

Reaction equation

HRID 1435811 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:8][C:9]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:10]=1[C:11](O)=[O:12]>>[NH2:8][C:9]1[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:10]=1[C:11]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1)=[O:12]

Participants

3

Reactant 2

HCID 79732-BromopyridineHCID 798582-Amino-5-bromobenzoic acid

Product 1

HCID 738072-(2-Amino-5-bromobenzoyl)pyridine

Procedure

The anion of 2-bromo-pyridine 121 and 2-amino-5-bromobenzoic acid 122 were condensed to provide the 2′-pyridylketone 123.

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-a008f6d77cbf40e98ec52500b2dea707
Source dataset
uspto-grants-2009_11
Patent number
US07618958B2

Reaction notes

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