Trifluoroacetic acid → 2-(S)-Amino-3-(3,5-difluorophenyl)-propan-1-ol trifluoroacetate
Reaction equation
C(OC(=O)[NH:7][C@H:8]([CH2:18][OH:19])[CH2:9][C:10]1[CH:15]=[C:14]([F:16])[CH:13]=[C:12]([F:17])[CH:11]=1)(C)(C)C.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>ClCCl>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[NH2:7][C@@H:8]([CH2:9][C:10]1[CH:11]=[C:12]([F:17])[CH:13]=[C:14]([F:16])[CH:15]=1)[CH2:18][OH:19]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Dissolve [2-(3,5-difluorophenyl)-1-(S)-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester (4.57 g, 15.9 mmol) in dichloromethane (20 mL). Add trifluoroacetic acid (20 mL) and stir 45 min and concentrate to give the title compound as a thick residue.