Methanol → HCID 136354592, compound

Reaction equation

OC1[C:3]2[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[C:7](=[NH:10])OC.[CH3:15][OH:16].[CH:17]([OH:20])([CH3:19])[CH3:18]>>[OH:16][C:15]1[C:3]2[CH:14]=[CH:13][CH:12]=[CH:11][C:4]=2[S:5][C:6]=1[C:7](=[NH:10])[O:20][CH:17]([CH3:19])[CH3:18]

Participants

Reactant 3

HCID 887Methanol

HCID 3776Isopropanol

HCID 3040798Benzo(b)thiophene-2-carboximidic acid, 3-hydroxy-, methyl ester

Product 1

HCID 136354592HCID 136354592, compound

Procedure

20 g of methyl 3-hydroxy-benzo[b] thiophene-2-carboximidate (Example 1) are heated under reflux in 500 ml of isopropanol for three days. The methanol being formed is constantly distilled off by passing through a stream of nitrogen. Evaporation to dryness and recrystallization of the residue from ethyl acetate yields yellow crystals with an m.p. of 208° C.