Benzyl 2-amino-2-methylpropanoate hydrochloride → Benzyl 2-amino-2-methylpropanoate
Reaction equation
Cl.[NH2:2][C:3]([CH3:15])([CH3:14])[C:4]([O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5]>C(OCC)(=O)C>[NH2:2][C:3]([CH3:15])([CH3:14])[C:4]([O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Benzyl 2-amino-2-methylpropionate hydrochloride (1.48 g) was dissolved in ethyl acetate (60 mL) and a saturated aqueous sodium hydrogen carbonate solution (20 mL), and the organic layer was separated. The organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give the title compound (1.2 g).
Workup
- customa saturated aqueous sodium hydrogen carbonate solution (20 mL), and the organic layer was separated
- washThe organic layer was washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was removed under reduced pressure
Sources & evidence
- ORD record
- ord-79df1b56083d4695b53e2b612188dd52
- Source dataset
- uspto-grants-2010_02
- Patent number
- US07655632B2
Reaction notes
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