Dimethylacetamide → Tert-butyl 6-[4-({[6-(3-fluorophenyl)pyridin-3-yl]carbonyl}amino)piperidin-1-yl]nicotinate

HRID 144396

Reaction equation

HRID 144396 reaction equation
[Br:23][c:24]1[n:25][cH:26][c:27]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[cH:35][cH:36]1.[CH3:37][N:38]([CH3:39])[C:40](=[O:41])[CH3:42].[F:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][cH:10][c:11]([C:12](=[O:13])[NH:14][CH:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[cH:21][cH:22]2)[cH:5][cH:6][cH:7]1>>[F:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][cH:10][c:11]([C:12](=[O:13])[NH:14][CH:15]3[CH2:16][CH2:17][N:18]([c:24]4[n:25][cH:26][c:27]([C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[cH:35][cH:36]4)[CH2:19][CH2:20]3)[cH:21][cH:22]2)[cH:5][cH:6][cH:7]1

Participants

4

Reactant 3

HCID 31374DimethylacetamideHCID 26369925(tert-Butyl) 6-bromonicotinateHCID 672679066-(3-fluorophenyl)-N-(piperidin-4-yl)nicotinamide

Product 1

HCID 59743962Tert-butyl 6-[4-({[6-(3-fluorophenyl)pyridin-3-yl]carbonyl}amino)piperidin-1-yl]nicotinate

Sources & evidence

ORD record
ord-06ad750374ba43138487686839a649fa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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