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Diisopropylethylamine → 4-(4-Cyclohexanecarbonyl-piperazine-1-carbonyl)-pyridin-2-ylmethyl-2H-phthalazin-1-one

HRID 1445711
Notes
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Reaction equation

HRID 1445711 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH2:12]C2C=C(C=CN=2)C(O)=O)=[N:4][NH:3]1.[CH:22]1([C:28]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[O:29])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1.CN(C(O[N:44]1N=N[C:46]2[CH:47]=[CH:48][CH:49]=[CH:50][C:45]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)CC)(C)C.CC[O:71]C(C)=O.CO>>[CH:22]1([C:28]([N:30]2[CH2:31][CH2:32][N:33]([C:12]([C:5]3[C:6]4[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=4)[C:2](=[O:1])[N:3]([CH2:50][C:49]4[CH:48]=[CH:47][CH:46]=[CH:45][N:44]=4)[N:4]=3)=[O:71])[CH2:34][CH2:35]2)=[O:29])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 5

HCID 81531DiisopropylethylamineHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 34375021-(Cyclohexylcarbonyl)piperazineHCID 21584119Ethylacetate methanolHCID 597677412-(4-Oxo-3,4-dihydro-phthalazin-1-ylmethyl)-isonicotinic acid

Product 1

HCID 131726981
4-(4-Cyclohexanecarbonyl-piperazine-1-carbonyl)-pyridin-2-ylmethyl-2H-phthalazin-1-one

Procedure

To a stirred solution of 2-(4-oxo-3,4-dihydro-phthalazin-1-ylmethyl)-isonicotinic acid (iva)(0.25 g, 0.89 mol) in diemthylacetamide (2 mL) was added cyclohexyl-piperazin-1-yl-methanone (0.20 g, 1.0 mmol) followed by HBTU (0.38 g, 1.0 mmol) and diisopropyl ethyl amine (0.35 mL, 20.0 mmol) and stirred. The reaction mixture was then concentrated in vacuo and resulting oil subjected to flash chromatography eluent 9:1 EtOAc/MeOH. (rf of 0.3) The titled compound was isolated as a white solid. Single peak in LC-MS analysis, (0.18 g, 56%); m/z (LC-MS, ESP), RT=4.07 mins, (M+H)=460; 1H NMR (300 MHz) 12.57 (1H, S —NH), 8.56 (1H, d, J=5.1 Hz), 8.26 (1H, dd, J 1.5, 8.1 Hz), 7.95-7.80 (3H, m), 7.38 (1H, S), 7.25 (1H, d, J=5.7 Hz), 4.51 (2H, S), 3.56-3.17 (8H, m), 2.58 (1H, m), 1.71-1.61 (5H, m), 1.38-1.22 (5H, m).

Workup

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. customresulting oil

Sources & evidence

ORD record
ord-609689888a85481b9c4cd2eac75092f0
Source dataset
uspto-grants-2010_02
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07666870B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes