Triethylamine → 1-benzyl-2-ethyl-1H-pyrrole

HRID 1445937

Reaction equation

HRID 1445937 reaction equation
[C:1]1(C2C=CC=CC=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][CH3:14].C1(C2C=CC=CC=2)C=CC=CC=1CN.C(N(CC)CC)C>C1C=CC=CC=1>[CH2:7]([N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[CH2:13][CH3:14])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:1]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2633661-Biphenyl-2-ylmethanamineHCID 591704071-(Biphenyl-2-ylmethyl)-2-ethyl-1h-pyrrole

Product 1

HCID 32494221-benzyl-2-ethyl-1H-pyrrole

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

1-(biphenyl-2-ylmethyl)-2-ethyl-1H-pyrrole, 13: To the crude 12 (14 g, 83 mmol) in dry benzene (200 mL) at room temperature is added biphenyl-2-ylmethanamine solution (100 mmol) and triethylamine (110 mmol). The solution is heated to reach 65° C. and stirred for 18 h. The resulted reaction mixture is filtered and concentrated. The crude product was purified by silica gel chromatography to afford 13

Workup

  1. temperatureThe solution is heated
  2. customto reach 65° C.
  3. customThe resulted reaction mixture
  4. filtrationis filtered
  5. concentrationconcentrated
  6. customThe crude product was purified by silica gel chromatography

Sources & evidence

ORD record
ord-6aecf2aef7954c0e9158959462e7c8ff
Source dataset
uspto-grants-2010_02
Patent number
US07666898B2

Linked notes

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