N-(2-Fluorophenyl)acetamide → N'-cyclopropyl-N-(2-fluorophenyl)-N-acetylurea
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=[O:11])[CH3:10].[CH:12]1([N:15]=[C:16]=[O:17])[CH2:14][CH2:13]1>O1CCCC1>[CH:12]1([NH:15][C:16](=[O:17])[N:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[C:9](=[O:11])[CH3:10])[CH2:14][CH2:13]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
A mixture of 5.8 g of 3A, 50 ml of tetrahydrofuran and 5.0 g of 1A was heated in a sealed glass cylinder for 12 hours at 100° C. Then the solvent was evaporated, and the residue was recrystallized from ether/hexane to give 3, as a white solid, m.p.: 43°-45° C.
Workup
- customThen the solvent was evaporated
- customthe residue was recrystallized from ether/hexane
- customto give 3
Sources & evidence
- ORD record
- ord-5f971edabde5429c91b99d46cfbaa9f9
- Source dataset
- uspto-grants-1982_02
- Patent number
- US04313755
Reaction notes
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