2-Hydrazinoethanol → Ethyl 1-(2-hydroxyethyl)-5-methylpyrazole-3-carboxylate
Reaction equation
[OH:1][CH2:2][CH2:3][NH:4][NH2:5].O=[C:7]([CH2:13][C:14](=O)[CH3:15])[C:8]([O:10][CH2:11][CH3:12])=[O:9].C(N1C(CC)=CC(C(O)=O)=N1)C>C(Cl)Cl>[OH:1][CH2:2][CH2:3][N:4]1[C:14]([CH3:15])=[CH:13][C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:5]1Participants
5
Procedure
The title compound was prepared from hydroxyethyl hydrazine (3.64 g, 50 mM) and ethyl 2,4-dioxovalerate (8.5 g, 50 mM) as described in Example 1 Preparation 1 as a colourless oil (9.39 g, 95%); νmax (CH2Cl2) 1700 cm-1 ; δH (CDCl3) 1.39 (3H, t, J7 Hz), 2.40 (3H, s), 2.98 (2H, t, J7 Hz), 4.33-4.48 (4H,m), and 6.39 (1H, s); E.I. m/e 198 (95% ).
Sources & evidence
- ORD record
- ord-41e34eae0f9e42aea56f76faff767500
- Source dataset
- uspto-grants-1997_02
- Patent number
- US05606051
Reaction notes
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