Oxalyl chloride → 4-Fluorobenzoyl isocyanate

HRID 1452516

Reaction equation

HRID 1452516 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.C(Cl)(=O)[C:12](Cl)=[O:13]>ClCCl>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:8]=[C:12]=[O:13])=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 715724-Fluorobenzamide

Product 1

HCID 27333754-Fluorobenzoyl isocyanate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.5 g of 4-fluorobenzamide was dissolved in 20 ml of dichloromethane and 2.3 ml of oxalyl chloride was slowly added thereto at room temperature, and then the mixutre was heated and refluxed for 16 hours. When the reaction was completed, the reaction mixture was cooled to room temperature and the solvent was distilled under reduced pressure to produce the titled compound as a oil. Without purification processes, next process was proceeded.

Workup

  1. temperaturerefluxed for 16 hours
  2. temperaturethe reaction mixture was cooled to room temperature
  3. distillationthe solvent was distilled under reduced pressure

Sources & evidence

ORD record
ord-6f7e71e2837f4a44b05ef245dccab01d
Source dataset
uspto-grants-2009_01
Patent number
US07473700B2

Linked notes

Loading…