Methyl iodide → HCID 68821354, compound
Reaction equation
[CH3:1][C:2]1[C:10]2[S:9](=[O:12])(=[O:11])[N:8]=[CH:7][NH:6][C:5]=2[S:4][CH:3]=1.[C:13](=O)([O-])[O-].[K+].[K+].IC>C(#N)C>[CH3:13][N:6]1[C:5]2[S:4][CH:3]=[C:2]([CH3:1])[C:10]=2[S:9](=[O:12])(=[O:11])[N:8]=[CH:7]1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 65 °C
Procedure
150 mg of the compound obtained in Step A above are suspended in 5 ml of acetonitrile. 300 mg of potassium carbonate and 0.15 ml of iodomethane are added thereto. The reaction mixture is heated at 65° C. for 30 minutes, with stirring. After evaporation of the solvents under reduced pressure, the residue is taken up in 5 ml of water and then collected by filtration, washed with water and dried.
Workup
- customAfter evaporation of the solvents under reduced pressure
- filtrationcollected by filtration
- washwashed with water
- customdried
Sources & evidence
- ORD record
- ord-57a84ff683de44b3b0c3dea3656a3a01
- Source dataset
- uspto-grants-2009_01
- Patent number
- US07476668B2
Reaction notes
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