Water → N-Cyclopropylmethyl-2-ethyl-7-iodo-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[1,5-a]pyridine-3-amine

HRID 145456

Reaction equation

HRID 145456 reaction equation
[CH2:30]([Li:31])[CH2:32][CH2:33][CH3:34].[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[CH3:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29].[CH:1]1([CH2:4][N:5]([CH2:6][CH:7]2[CH2:8][CH2:9][O:10][CH2:11][CH2:12]2)[c:13]2[c:14]([CH2:22][CH3:23])[n:15][n:16]3[c:17]2[cH:18][cH:19][cH:20][cH:21]3)[CH2:2][CH2:3]1.[F:35][c:36]1[c:37]([I:42])[c:38]([F:39])[c:40]([F:41])[c:43]([F:44])[c:45]1[F:46].[O:53]1[CH2:54][CH2:55][CH2:56][CH2:57]1.[OH2:47]>>[CH:1]1([CH2:4][N:5]([CH2:6][CH:7]2[CH2:8][CH2:9][O:10][CH2:11][CH2:12]2)[c:13]2[c:14]([CH2:22][CH3:23])[n:15][n:16]3[c:17]2[cH:18][cH:19][cH:20][c:21]3[I:42])[CH2:2][CH2:3]1

Participants

7

Reactant 6

HCID 962WaterHCID 8028Tetrahydrofuran2×HCID 8058HexaneHCID 70008PentafluoroiodobenzeneHCID 58801672N-Cyclopropylmethyl-N-(2-ethylpyrazolo[1,5-a]pyridin-3-yl)-N-tetrahydro-2H-4-pyranylmethylamineHCID 178418339Butyllithium

Product 1

HCID 11339625N-Cyclopropylmethyl-2-ethyl-7-iodo-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[1,5-a]pyridine-3-amine

Sources & evidence

ORD record
ord-c438df3073f645deb43f1f1f82dce6aa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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