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Triethylamine → Methyl 3-[2-[2-(4-fluorophenyl)ethoxy]ethylaminosulphonyl]propanoate

HRID 1457043
Notes
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Reaction equation

HRID 1457043 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][O:10][CH2:11][CH2:12][NH2:13])=[CH:4][CH:3]=1.C(N(CC)CC)C.Cl[S:22]([CH2:25][CH2:26][C:27]([O:29][CH3:30])=[O:28])(=[O:24])=[O:23]>C(OCC)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][O:10][CH2:11][CH2:12][NH:13][S:22]([CH2:25][CH2:26][C:27]([O:29][CH3:30])=[O:28])(=[O:24])=[O:23])=[CH:6][CH:7]=1
ParticipantsProcedureSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 4962888Methyl 3-(chlorosulfonyl)propanoateHCID 187790642-[(4-Fluorophenethyl)oxy]ethylamine

Product 1

HCID 18779017Methyl 3-[2-[2-(4-fluorophenyl)ethoxy]ethylaminosulphonyl]propanoateYield 85.3%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent
On this pageParticipantsProcedureSources & evidenceReaction notes

Procedure

The subtitle compound (8.32 g) was prepared according to the method of Example 3d) using 2-[2-(4-fluorophenyl)ethoxy]ethanamine (5.36 g), triethylamine (4.6 ml) and methyl 3-(chlorosulphonyl)propanoate (5.6 g) in diethyl ether (150 ml).

Sources & evidence

ORD record
ord-7fb6b5ab641447d5831ba963be1b33dd
Source dataset
uspto-grants-1998_12
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05846989

Reaction notes

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