Hydrochloric Acid → Benzoic acid, m-(bis(2-chloroethyl)amino)-
Reaction equation
Cl.[Cl:2][CH2:3][CH2:4][N:5]([C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([O:14]C)=[O:13])[CH2:6][CH2:7][Cl:8]>O>[Cl:2][CH2:3][CH2:4][N:5]([C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([OH:14])=[O:13])[CH2:6][CH2:7][Cl:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Concentrated hydrochloric acid (40 ml) was added to 2.0 g (7.44 mmol) of methyl 3-[N,N-bis(2-chloroethyl)amino]benzoate, followed by stirring under heating for 3 hours over an oil bath which was controlled at 90° C. The reaction mixture was diluted with water. The resulting crystals were collected by filtration and then washed with 50% ethanol, whereby 1.95 g (7.44 mmol) of the title compound were obtained as white crystals (yield: quantitative).