Isobutyl chloride → 2-Isopropyl-5-nitrobenzofuran

HRID 1459677

Reaction equation

[Br-].[OH:2][C:3]1[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][C:4]=1[CH2:5]P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[CH2:32](Cl)[CH:33]([CH3:35])[CH3:34]>>[CH:33]([C:35]1[O:2][C:3]2[CH:28]=[CH:27][C:26]([N+:29]([O-:31])=[O:30])=[CH:25][C:4]=2[CH:5]=1)([CH3:34])[CH3:32]

Participants

Reactant 2

HCID 10554Isobutyl chloride

HCID 178526701HCID 178526701, compound

Product 1

HCID 544749412-Isopropyl-5-nitrobenzofuran

Procedure

Reaction of 2-hydroxy-5-nitrobenzyl triphenylphosphine bromide (prepared as described in Example 1(a) (40 g, 0.08 mol) and isobutyl chloride (10,6, 0.1. mol) was carried out with the method described in Example 1(b) to produce 19.7 g of 2-isopropyl-5-nitrobenzofuran.

Workup

customprepared

Sources & evidence

ORD record: ord-619f38cb936a4a90b63a1621d3d358db
Source dataset: uspto-grants-1998_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05854282

Linked notes

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