HCID 136341208, compound → 2-Amino-4-fluoro-6-methylphenol
Reaction equation
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]([OH:9])[C:4](C2C=CC=CC=2)([N:10]=NC2C=CC=CC=2O)[CH:3]=1>C(OCC)(=O)C.[Pd]>[NH2:10][C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([CH3:8])[C:5]=1[OH:9]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A mixture of 5.75 g (25 mmoles) of 4-fluoro-6-methyl-2-phenylazophenol (B1) and 1.1 g of 5% Pd/c in ethyl acetate was shaken in a Parr shaker under hydrogen at room temperature for 17.5 hours. The reaction mixture was filtered through celite and the filtrate concentrated to an oil which was purified on silica gel eluting with hexane-ethyl acetate, giving 3.2 g of a white solid: m.p. 97° C. (dec).
Workup
- filtrationThe reaction mixture was filtered through celite
- concentrationthe filtrate concentrated to an oil which
- customwas purified on silica gel eluting with hexane-ethyl acetate
Sources & evidence
- ORD record
- ord-7705d81af164466f81711407ae904e9e
- Source dataset
- uspto-grants-1991_12
- Patent number
- US05071863
Reaction notes
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