Ethanol → 2-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde

HRID 1460678Notes

Reaction equation

HRID 1460678 reaction equation
C[O:2][CH:3](OC)[C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][CH:13]([NH:16][C:17](=[O:19])[CH3:18])[CH2:12][CH2:11]2)[CH:7]=[CH:6][C:5]=1[N+:20]([O-:22])=[O:21].C=O.C(O)C>Cl.O>[N+:20]([C:5]1[CH:6]=[CH:7][C:8]([N:10]2[CH2:11][CH2:12][CH:13]([NH:16][C:17](=[O:19])[CH3:18])[CH2:14][CH2:15]2)=[CH:9][C:4]=1[CH:3]=[O:2])([O-:22])=[O:21]

Participants

6

Reactant 3

HCID 702EthanolHCID 712FormaldehydeHCID 190868632-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal

Product 1

HCID 190868462-Nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidCatalystHCID 962WaterSolvent

Procedure

0.3 Gram of 2-nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde dimethylacetal, 5 ml of formalin, 1 ml of ethanol and 2 drops of concentrated hydrochloric acid were refluxed by heating. After the reaction was completed, the solvent was removed by evaporation to obtain the residue, then water was added to the residue. The crystals formed were collected by filtration to yield 0.22 g of 2-nitro-5-(4-acetylamino-1-piperidyl)benzaldehyde.

Workup

  1. temperatureby heating
  2. customthe solvent was removed by evaporation
  3. customto obtain the residue
  4. customThe crystals formed
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-a500e6d154d94be0b110e84b4341736f
Source dataset
uspto-grants-1991_12
Patent number
US05071856

Reaction notes

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