Chloroform → 1-(4-Morpholinyl)-1-dodecanone
Reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[C:13](Cl)(=[O:25])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24].C(Cl)(Cl)Cl>O>[O:25]=[C:13]([N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1)[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
Example 1(A) was repeated using morpholine, potassium carbonate and dodecanoyl chloride in a biphasic mixture of chloroform and water followed by the usual workup to obtain the above product.
Workup
- customto obtain the above product
Sources & evidence
- ORD record
- ord-a4dc46b694df45868ba266f027a857b5
- Source dataset
- uspto-grants-1991_12
- Patent number
- US05073544
Reaction notes
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