Tetrahydrofuran → HCID 10379719, compound
Reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([C:9]1([CH3:26])[CH2:12][N:11]([CH:13]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10]1)#[N:8].O1CC[CH2:29][CH2:28]1>>[C:14]1([CH:13]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:11]2[CH2:10][C:9]([CH2:7][NH:8][CH2:28][CH3:29])([CH3:26])[CH2:12]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1Participants
4
Procedure
6.1 g (161 mmol) of lithium aluminium hydride are suspended in 250 ml of tetrahydrofuran, and a solution of 21.1 g (80.5 mmol) of 3-cyano-1-diphenylmethyl-3-methylazetidine in 150 ml of tetrahydrofuran are added dropwise during 1 hour. The temperature is maintained during the addition at between 30° and 35° C. and the mixture is then stirred for 12 hours at room temperature. The excess lithium aluminium hydride is destroyed with ethanol, the insoluble inorganic fraction is filtered off, the tetrahydrofuran is removed, the residue is dissolved with chloroform, the organic phase is washed with water, dried with anhydrous sodium sulphate and evaporated to dryness and 16.1 g (75%) of 3-aminomethyl-1-diphenylmethyl-3-methylazetidine, melting point 46°-8° C., are obtained.